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ClinicalTrials.gov (2026) 11

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Any references to appetite signaling, energy expenditure, satiety, or food intake are limited to experimental research context only and do not imply approved human or veterinary use

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An exploratory subgroup analysis of five PIONEER trials (35, 7, and 8) assessed the potential impact of different background medications (metformin, SU, SGLT2i, insulin, or combinations) on the efficacy and safety of oral semaglutide and comparators [71]